Description
Survodutide (BI 456906) is a fatty acid-modified peptide acting as a dual agonist at the glucagon-like peptide-1 receptor and the glucagon receptor, designed to leverage complementary mechanisms: GLP-1R activation for glucose-dependent insulin secretion and appetite suppression, and GCGR activation for increased hepatic glucose production flux and thermogenic energy expenditure. In preclinical models, dual GLP-1/glucagon co-agonism has demonstrated additive or synergistic effects on body weight and hepatic lipid content relative to GLP-1R-only agonism, making this compound class an area of substantial mechanistic research interest.
This lyophilized reference peptide is intended for in vitro receptor pharmacology work, rodent obesity and metabolic syndrome models, and comparative studies within the dual incretin agonist drug class. Strict low-temperature storage (-20 degrees Celsius) is recommended to preserve biological activity. Each vial is sealed under inert conditions for maximum shelf stability. For laboratory research use only. Not for human or veterinary use.





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