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5-Amino-1MQ

Price range: $80.00 through $175.00

In Stock99%+ PurityThird-Party Tested

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) studied in preclinical metabolic research for its effects on adipocyte differentiation and cellular NAD⁺ flux. Supplied as a research-grade compound. For laboratory research use only. Not for human or veterinary use.

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For laboratory research use only. Not for human or veterinary use.

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SKU: N/A Category: GLP & Incretin Analogues

Description

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a selective, membrane-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme responsible for methylating nicotinamide to 1-methylnicotinamide. By blocking NNMT activity, 5-Amino-1MQ has been shown in preclinical cell and animal studies to elevate intracellular SAM and NAD⁺ pools, resulting in enhanced SIRT1/AMPK activity and inhibition of adipogenesis. Investigators have employed it as a tool compound to study the intersection of one-carbon metabolism, epigenetic programming, and energy homeostasis in white adipose tissue models.

Dorado Research offers 5-Amino-1MQ as a high-purity lyophilized powder verified by NMR and LC-MS, suitable for dissolution in DMSO or aqueous co-solvents for in vitro assay use. The compound is intended exclusively as a biochemical research tool for qualified laboratory applications, including enzyme inhibition kinetics, transcriptomic profiling, and metabolic flux analysis. For laboratory research use only. Not for human or veterinary use.