2X Tesamorelin / Ipamorelin

Description

This combination provides two mechanistically complementary growth hormone secretagogue peptides in a single research set. Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH) that binds the GHRH receptor on pituitary somatotrophs, stimulating pulsatile GH release while mirroring the physiological activity of endogenous GHRH. Ipamorelin is a selective, third-generation growth hormone secretagogue and ghrelin receptor (GHSR-1a) agonist known for its high GH specificity with minimal off-target stimulation of ACTH, cortisol, or prolactin — a property that makes it a favored tool peptide for mechanistic axis studies. Together they engage distinct receptor pathways converging on GH release, enabling research designs that probe GHRH-GHS synergy, pituitary responsiveness, IGF-1 downstream signaling, and the differential pharmacology of GHRH-R versus GHSR-1a.

Both peptides are supplied as individually sealed lyophilized vials of research-grade purity, suitable for reconstitution in sterile aqueous vehicles for cell-based pituitary assays, rodent GH secretion models, and comparative pharmacokinetic studies. Storage at -20 degrees Celsius is recommended. Researchers should reconstitute each vial separately per validated protocols for the intended experimental system. For laboratory research use only. Not for human or veterinary use.