Description
ARA-290 is an 11-amino acid cyclic peptide engineered to selectively engage the innate repair receptor (IRR) — a heterodimer of the erythropoietin receptor (EPOR) and the common beta receptor (βc) — without stimulating erythropoiesis. This molecular selectivity makes it a precise research tool for studying tissue-protective and anti-inflammatory pathways entirely independently of the hematopoietic side effects associated with full-length EPO.
Preclinical investigations have demonstrated ARA-290’s capacity to reduce pro-inflammatory cytokine cascades, promote neuronal survival under metabolic stress, and attenuate neuropathic pain signaling in peripheral nerve injury models. Research with ARA-290 10mg spans neuroscience, metabolic disease, and immune modulation disciplines, where investigators leverage its IRR-specific activity to map the downstream signaling consequences of innate repair receptor engagement across diverse tissue contexts. For laboratory research use only. Not for human or veterinary use.





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