Description
Melanotan-1, also designated afamelanotide, is a linear synthetic alpha-MSH analogue engineered for enhanced receptor affinity and metabolic stability relative to the native 13-amino acid peptide. It binds with high selectivity to the melanocortin-1 receptor (MC1R) expressed on epidermal melanocytes, stimulating eumelanin synthesis via cAMP-dependent signaling. Preclinical research has investigated its role in pigmentation biology, UV-induced DNA damage responses, and photoprotective mechanisms in human and murine skin cell models.
This lyophilized peptide is supplied for in vitro receptor binding studies, melanocyte culture assays, and comparative pharmacological investigations within the melanocortin receptor family. Solubility in sterile water or physiological buffer enables flexible experimental design. Vials are sealed for integrity and should be stored at -20 degrees Celsius to maintain structural stability prior to reconstitution. For laboratory research use only. Not for human or veterinary use.
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