PT-141

Description

PT-141 (bremelanotide) is a synthetic cyclic heptapeptide derived from the endogenous α-melanocyte-stimulating hormone (α-MSH). Unlike peripherally acting vasoactive agents, PT-141 engages melanocortin receptor subtypes MC3R and MC4R within the hypothalamus, making it a pharmacological probe for centrally mediated neuroendocrine signaling. Preclinical behavioral and electrophysiological studies have utilized PT-141 to dissect the role of melanocortin circuits in appetitive motivation, arousal-state regulation, and reward pathway modulation across rodent and non-human primate models.

Dorado Research provides PT-141 as a high-purity lyophilized powder characterized by HPLC and mass spectrometry. The compound is packaged in UV-protective vials to preserve cyclic integrity during storage and shipment. It is supplied exclusively as a research-grade reference material intended for in vitro receptor binding assays, cell signaling studies, and laboratory pharmacology investigations. For laboratory research use only. Not for human or veterinary use.