NAD+

Description

Nicotinamide adenine dinucleotide (NAD⁺) is a ubiquitous dinucleotide coenzyme that serves as an essential electron carrier in oxidative phosphorylation and as a substrate for regulatory enzymes including the sirtuin family of protein deacylases (SIRT1–7), poly(ADP-ribose) polymerases (PARPs), and CD38 glycohydrolase. Research over the past decade has established that intracellular NAD⁺ levels decline with age in multiple tissues, correlating with diminished mitochondrial function, impaired DNA damage repair, and altered circadian clock entrainment. NAD⁺ and its precursors are now central reference compounds in studies of caloric restriction mimicry, sirtuin pharmacology, PARP inhibition, and the aging metabolome.

Dorado Research supplies NAD⁺ as a high-purity lyophilized reagent characterized by HPLC and certified for use in enzymatic assays, mass spectrometry-based metabolomics, and cell-based bioenergetics experiments. The compound is packaged under inert atmosphere in amber vials to minimize photodegradation. It is intended exclusively as a laboratory reference standard for qualified in vitro and biochemical research applications. For laboratory research use only. Not for human or veterinary use.